From SCI-FI Wire

Rosanna Arquette, who plays a murderous older woman in an upcoming episode of her sister Patricia’s NBC series Medium, told SCI FI Wire that killing a man on screen made her queasy.

“It was challenging,” Rosanna Arquette said during a conference call with journalists last week on which she was joined by Patricia. “There was this one moment where I had to strangle this man, and I found myself getting really nauseous. Like, every time I would do [a take], I kind of felt sick to my stomach, and I said, ‘This feeling … comes because that is wrong.’ It’s amazing, the people who actually really do these things, how they can get to that place.”

In the episode titled “Lady Killer,” Rosanna Arquette’s homicidal actions appear in the dreams of psychic Allison DuBois (Patricia Arquette). Eventually, the two women meet face to face during interrogation sequences.

Patricia Arquette said that she and Rosanna have previously appeared together in Rosanna’s documentary Searching for Debra Winger. But “Lady Killer” marked the first time they’d worked together in a fictional piece. And her sister’s performance as the murderous “cougar” impressed her, she added.

“I thought, you know, because I know my sister so well, that it’s a testament to what a great actress she is,” Patricia Arquette said. “I mean, physically, she is a very beautiful woman, but she’s a very natural woman in real life. So … I knew she would look gorgeous, and she looks gorgeous. But to see her as this sort of carnivorous mercenary, kind of dangerous person, … [it was] so different for me to see her [as] that.”

“Lady Killer” premieres April 7 at 10 p.m. ET/PT. (NBC is owned by NBC Universal, which also owns SCIFI.COM.) –Ian Spelling